FGF1 stops diabetes in its tracks

Stopping Ras in Its Tracks

Ras interacts with many downstream effectors that regulate complex cytoplasmic signaling networks. In this issue, Gupta et al. (2007) use mouse models of Ras-mediated tumorigenesis to show that the interaction of Ras with a single isoform of phosphatidylinositol 3-kinase (PI3K), called p110alpha (PIK3CA), is critical for tumor formation. This result will stimulate re-evaluation of pharmacologic...

Stopping MYC in its tracks

a transcriptional regulator that in order to function has to dimerize with a specific partner protein, MAX. The MYC-MAX dimer regulates the expression of thousands of genes involved in fundamental cellular processes including growth, proliferation, differentiation, biosynthesis, energy metabolism, and apoptosis [1-3]. The discovery that MYC becomes overexpressed as a result of chromosomal rearr...

CAMs are stopping cancer in its metastatic tracks.

A counterintuitive idea is making the rounds in cancer research: Stickiness promotes mobility. Proteins that help cells stick together, called cellular adhesion molecules (CAMs), may be a driving force in metastasis, and they seem to be present in almost every cancer tested. The good news is that blocking CAMs seems to slow the spread of cancer. In fact, using antibodies to interfere with CAMs ...

LANDesk® Host Intrusion Prevention System A New HIPS Solution that Stops Zero-Day Attacks in their Tracks

Increased Protein Stability of FGF1 Can Compensate for Its Reduced Affinity for Heparin*

Human FGF1 (fibroblast growth factor 1) is a powerful signaling molecule with a short half-life in vivo and a denaturation temperature close to physiological. Binding to heparin increases the stability of FGF1 and is believed to be important in the formation of FGF1.fibroblast growth factor receptor (FGFR) active complex. In order to reveal the function of heparin in FGF1.FGFR complex formation...